Toxicokinetic modeling of the transfer of polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) into milk of high-yielding cows during negative and positive energy balance
A toxicokinetic modeling approach was used to study the transfer of 7 polychlorinated dibenzo-p-dioxins (PCDDs), 10 dibenzofurans (PCDFs), 12 dioxin-like polychlorinated biphenyls (dl-PCB) and 3 non-dioxin like (ndl) PCBs in dairy cows. The model describes the concentration–time profile of each congener in milk and blood of high-yielding dairy cows. The results draw attention to the influence of the metabolic state of food-producing animals in risk assessment. Comparison of the transfer rates derived here with those reported in the literature showed that they were, in median, 43% higher in the negative energy balance after calving phase and 16% higher in the positive energy balance in late lactation phase.
The article was published in the journal Computational Toxicology.
Toxicokinetic modeling of the transfer of polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) into milk of high-yielding cows during negative and positive energy balance
Jan-Louis Moenning, Julika Lamp, Karin Knappstein, Joachim Molkentin, Andreas Susenbeth, Karl-Heinz Schwind, Sven Dänicke, Peter Fürst, Hans Schenkel, Robert Pieper, Torsten Krause, Jorge Numata
Computational Toxicology
Volume 28
2023, 100290