The adverse outcome pathway for breast cancer: a knowledge management framework bridging biomedicine and toxicology
The rapid progress of biomedical and toxicological research in recent years now allows the pursuit of new approaches based on non-animal methods. These provide greater mechanistic insight than traditional animal models and therefore facilitate the development of Adverse Outcome Pathways (AOPs) for human diseases. The authors performed a systematic review of the current state of published knowledge with regard to breast cancer to identify relevant key mechanisms for inclusion into breast cancer AOPs, i.e. decreased cell stiffness and decreased cell adhesion, and to concurrently map non-animal methods addressing these key events.
The article was published in the journal "Discover Oncology".
The adverse outcome pathway for breast cancer: a knowledge management framework bridging biomedicine and toxicology
von Coburg, E., Dunst, S. .
Discov Onc 14, 223 (2023).