A comparative assessment of the CLP calculation method and in vivo testing for the classification of plant protection products

In Europe, animal testing for the purpose of regulatory plant protection product (PPP) assessment should be undertaken only as a last resort. The CLP calculation method is an alternative method based on the concentration addition of all adverse substances in a mixture. Our analysis revealed that oral and inhalation toxicity was underestimated for approximately 45% of the in vivo classified products by the CLP calculation method as compared to in vivo testing. Hence, we suggest the development of an integrated assessment strategy, weighing all available information and considering relevant parameters influencing predictivity and uncertainty.

The study was published in Regulatory Toxicology and Pharmacology.

A comparative assessment of the CLP calculation method and in vivo testing for the classification of plant protection products
Denise Kurth, Korinna Wend, Sarah Adler-Flindt, Sabine Martin

Regulatory Toxicology and Pharmacology
Published: Online 22 November 2018. Print: February 2019
Volume 101,
Pages 79-90
DOI: 10.1016/j.yrtph.2018.11.012
https://doi.org/10.1016/j.yrtph.2018.11.012